Systematic review and meta-analysis: migraine and cardiovascular disease
How can we use meta-analysis to look for association?
Migraine is a common disorder that is somewhat commoner in women than in men. A chronic recurring illness, migraine presents with episodic and often severe and even debilitating headaches that may be associated with symptoms of the gastrointestinal and nervous systems. About 30% of patients develop an aura before or during the attack. An aura may be visual or neurological and is a symptom in addition to the headache, such as flashing lights or other sensory changes.
As the authors of this paper point out, migraine has also been consistently linked to an increased risk of ischaemic stroke. Some studies have associated it with an increase in the risk of myocardial infarction and death because of cardiovascular disease.
The authors decided to review the published evidence relating to any association between migraine and ischaemic stroke, myocardial infarction, and death because of cardiovascular disease. They were particularly interested in the relevance