C reactive protein
A common test for inflammation and infection
- By: Omer Farhan-Alanie, Veer Shah, Naveed Sattar
C reactive protein (CRP) was discovered in 1930 in the serum of patients with acute inflammation.1 Nowadays, the CRP test is a routine blood test done to measure general levels of inflammation and infection in the body, determine their severity, and monitor response to treatment. With the discovery of an association between CRP and risk of cardiovascular events, some researchers have recommended its use to assess risk of cardiovascular disease as well as to guide and gauge response to treatment with statins.
CRP is one of many plasma proteins that comprise the “acute phase proteins” and is a sensitive systemic marker of inflammation. It is synthesised by the liver in response to microbial infection, tissue injury, and autoimmune disorders in the acute phase of the response. This phase of the response comprises non-specific physiological and biochemical reactions to most forms of tissue damage, infection, inflammation, and malignant neoplasia. The synthesis