ß-Amyloid: ß-Amyloid protein causes problems only when it is converted from its normal soluble form to insoluble ß-pleated sheets, which accumulate into neurotoxic amyloid plaques. In its healthy role it is probably involved in stabilising cell walls.
Prions: These are proteins produced by the prion gene and probably have a role in maintaining the electrical activity of cells. In Creutzfeldt-Jakob disease, the normal soluble form changes its configuration by folding up differently, allowing it to form insoluble ß -pleated sheet structures. The protein forms prion plaques that are neurotoxic. The pathological changes are transmissible.
*-Synuclein: This protein is found in Parkinson's disease and dementia with Lewy bodies. Its role in the normal state is unclear. In pathological states this protein forms intraneuronal inclusions (Lewy bodies).
Tau: This protein is found in the microtubules of nerve cells, and its role is to help stabilise them. The role of microtubules is to