Each week the BMJ publishes a clinical review. Here is a recent one that covered osteoarthritis, by David J Hunter and David T Felson
Osteoarthritis is the most prevalent form of arthritis, with an associated risk of mobility disability (defined as needing help walking or climbing stairs) for those with affected knees being greater than that due to any other medical condition in people aged ≥ 65.1 The societal burden (both in terms of personal suffering and use of health resources) is expected to increase with the increasing prevalence of obesity and the ageing of the community.
Osteoarthritis is a multifactorial process in which mechanical factors have a central role and is characterised by changes in structure and function of the whole joint.2 There is no cure, and current therapeutic strategies are primarily aimed at reducing pain and improving joint function. We concentrated on osteoarthritis of the knee as this is associated with the greatest public health burden.
Osteoarthritis is the clinical and pathological outcome of a range of disorders that results in structural