The laureate, the worm, and RNAi
Craig Mello is one of the two joint winners of the 2006 Nobel prize in physiology or medicine, for the “discovery of RNA interference gene silencing by double stranded RNA.” Ajit Goenka and Hrishikesh Kulkarni caught up with him
- By: Ajit Goenka, Hrishikesh Kulkarni
It is where double stranded RNA inhibits the expression of genes with complementary nucleotide sequences. This phenomenon is proving to be an extraordinary research tool. The realisation that RNAi is a normal means of genetic regulation has opened up a fascinating yet hitherto inconceivable vista in the field of developmental gene regulation. Moreover, RNAi offers tremendous prospects for understanding and manipulating the cellular basis of human diseases.
Absolutely. What is most essential is to have a lot of motivation. It is not easy being a scientist; one has to learn to enjoy the work that one does. You should have things you enjoy outside your laboratory when things do not go your way. It is also important to be at the right place at the right time and to work with the right kind of people.
I was really fortunate to be able to share my ideas with a magnificent